If an image is worth a thousand words, a movie drives home the message of a thousand images. For this three-dimensional visualization of amyloid deposition in the brain of a person with mild Alzheimer disease, PET images obtained after injecting the amyloid tracer PIB were superimposed on the magnetic resonance image of the same patient. The patient’s MMSE was 25. The movie shows extensive amyloid deposition in cortical and deep brain areas.This patient’s amyloid probably won’t spread much further as disease progresses. In fact, PIB imaging studies comparing AD patients, people with mild cognitive impairment, presymptomatic carriers of familial AD mutations, and healthy controls are indicating that a person’s amyloid load has more or less fully formed even before they develop symptoms of AD. The relationship of amyloid deposition and AD symptoms over time is the subject of current studies. Video credit: Scott Ziolko and the Pittsburgh Amyloid Imaging Group.
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