Synapses in backgear

This is what I call "Reverse Engineering". Synapses backfire ! PSD-95 is the name of the game as a team lead by Kensuke Futai et al at Riken's Research found out. They wrote... “Beta-amyloid accumulation, which is a major symptom of Alzheimer's disease, causes the loss of PSD-95 from synapse,” says Futai. “It’s perhaps not unexpected that Alzheimer's patients have less PSD-95 since Alzheimer’s patients cannot maintain memories, and because PSD-95 is important for synaptic function.” Yet, increasing the amount of PSD-95 in Alzheimer-diseased neurons to treat memory problems is not very realistic at present, he adds. Other types of trans-synaptic molecules factors still await intensive study. “I would like to apply [the] same technology we used [in] the present study to other trans-synaptic and retrograde molecules. By doing further studies, I think we will understand better how synapses [memories] are maintained [stored] in the brain,” says Futai. “Regarding further work on PSD-95–neuroligin–β-neurexin, I would also like to know if a relationship exists between these protein-protein interactions and the development of autism.”