Although a tight relationship between neuronal cortical activity and regional blood flow in response to its metabolic demand is tacitly accepted as the base for fMRI BOLD signals it is known that this relationship is not always very quantitatively linear and often dependent on local circumstances. However Sirotin and Das have taken this to a new extreme by showing increase in blood flow in anticipation of a stimulus that is not deliverd (no activation in neural activity).
A fascinating story this week in nature. Read a summary here....
21 januari 2009
A BOLD mismatch
Although a tight relationship between neuronal cortical activity and regional blood flow in response to its metabolic demand is tacitly accepted as the base for fMRI BOLD signals it is known that this relationship is not always very quantitatively linear and often dependent on local circumstances. However Sirotin and Das have taken this to a new extreme by showing increase in blood flow in anticipation of a stimulus that is not deliverd (no activation in neural activity).
A fascinating story this week in nature. Read a summary here....
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