Guan, J., Haggarty, S., Giacometti, E., Dannenberg, J., Joseph, N., Gao, J., Nieland, T., Zhou, Y., Wang, X., Mazitschek, R., Bradner, J., DePinho, R., Jaenisch, R., & Tsai, L. (2009). HDAC2 negatively regulates memory formation and synaptic plasticity Nature, 459 (7243), 55-60 DOI: 10.1038/nature07925
08 mei 2009
reversing fate
HDAC2 negatively regulates memory formation and synaptic plasticity p55
Histone acetylation has been implicated in learning and memory. Neuron-specific overexpression of histone deacetylase 2 (HDAC2), but not HDAC1, is shown to decrease memory formation in a rodent model. This encourages development and testing of HDAC2-selective inhibitors for human diseases associated with memory impairment.
Ji-Song Guan, Stephen J. Haggarty, Emanuela Giacometti, Jan-Hermen Dannenberg, Nadine Joseph, Jun Gao, Thomas J. F. Nieland, Ying Zhou, Xinyu Wang, Ralph Mazitschek, James E. Bradner, Ronald A. DePinho, Rudolf Jaenisch & Li-Huei Tsai
Guan, J., Haggarty, S., Giacometti, E., Dannenberg, J., Joseph, N., Gao, J., Nieland, T., Zhou, Y., Wang, X., Mazitschek, R., Bradner, J., DePinho, R., Jaenisch, R., & Tsai, L. (2009). HDAC2 negatively regulates memory formation and synaptic plasticity Nature, 459 (7243), 55-60 DOI: 10.1038/nature07925
Guan, J., Haggarty, S., Giacometti, E., Dannenberg, J., Joseph, N., Gao, J., Nieland, T., Zhou, Y., Wang, X., Mazitschek, R., Bradner, J., DePinho, R., Jaenisch, R., & Tsai, L. (2009). HDAC2 negatively regulates memory formation and synaptic plasticity Nature, 459 (7243), 55-60 DOI: 10.1038/nature07925
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