These two papers kind of smack a lot of highschool-college-gradschool molecular
biology in the face. A cornerstone of neuroscience for a while has been the
understanding that mRNA is translated proximal to the nucleus and proteins
undergo trafficking to distal locations.
This is, in fact, the basis of neural networking studies using combinations
of in-situ-hybridization and other immunohistochemical techniques.
The new understanding is that the message is sitting in a distant location,
waiting for an interpreter to get there. Once the neuron gets sufficient
stimulation, it sends the interpreter to translate and reorganize
cytoarchitecture based on the directions that were just sitting in wait.
This is reallly cooool for anybody studying neuroplacticity.