Geneticists know nothing about psychiatric disease.”
Daniel Weinberger
Finding genes involved in psychiatric conditions is proving to be particularly intractable because it is still unclear whether the various diagnoses are actually separate diseases with distinct underlying genetics or whether, as the DISC1 story suggests, they will dissolve under the genetic spotlight into one biological continuum. Indeed, some researchers suggest that it would be better to abandon conventional clinical definitions and focus instead on 'intermediate phenotypes', quantifiable characteristics such as brain structure, wiring and function that are midway between the risk genes involved and the psychopathology displayed.
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